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OCR: ed for Specific enzymes and cofactors are requi s. These glucocorticoid and androgen biosynthes enzymes are located either in the smoot ondria endoplasmic reticulum or in the mitoch between within each cell. Movement of substrate nd this these organelles is therefore necessary, a y require mechanism of intracellular transport m atracellularspecific steroid-binding proteins. Thus, i arlier feedback effects of intermediates in the e in biosynthetic steps may be of importance regulating cholesterol biosynthesis, See later: · Hydroxylation of Steroids